NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-12 | Lafayette (292) | 63 | 72 | Pittsburgh (279) | Final | L | -9 |
| 2 | 2021-11-14 | Lafayette (221) | 47 | 60 | Duquesne (246) | Final | L | -13 |
| 3 | 2021-11-18 | Columbia (44) | 72 | 59 | Lafayette (292) | Final | L | -13 |
| 4 | 2021-11-20 | Siena (292) | 44 | 49 | Lafayette (328) | Final | W | 5 |
| 5 | 2021-11-23 | Lafayette (292) | 52 | 73 | La Salle (143) | Final | L | -21 |
| 6 | 2021-11-28 | Cornell (274) | 66 | 55 | Lafayette (267) | Final | L | -11 |
| 7 | 2021-12-01 | Marist (230) | 50 | 53 | Lafayette (317) | Final | W | 3 |
| 8 | 2021-12-04 | NJIT (179) | 64 | 71 | Lafayette (292) | Final | W | 7 |
| 9 | 2021-12-09 | Lafayette (263) | 62 | 55 | UMBC (340) | Final | W | 7 |
| 10 | 2021-12-12 | Lafayette (263) | 36 | 71 | Fordham (51) | Final | L | -35 |
| 11 | 2021-12-22 | Lafayette (272) | 0 | 0 | Long Island (339) | Postponed | - | - |
| 12 | 2021-12-29 | Lafayette (273) | 59 | 37 | Colgate (343) | Final | W | 22 |
| 13 | 2022-01-02 | American (316) | 0 | 0 | Lafayette (292) | Postponed | - | - |
| 14 | 2022-01-05 | Holy Cross (121) | 0 | 0 | Lafayette (292) | Postponed | - | - |
| 15 | 2022-01-08 | Lafayette (292) | 54 | 44 | Navy (127) | Final | W | 10 |
| 16 | 2022-01-12 | Loyola-Maryland (258) | 39 | 48 | Lafayette (292) | Final | W | 9 |
| 17 | 2022-01-15 | Army (200) | 62 | 56 | Lafayette (240) | Final | L | -6 |
| 18 | 2022-01-19 | Lafayette (292) | 57 | 63 | Holy Cross (121) | Final | L | -6 |
| 19 | 2022-01-22 | Colgate (340) | 49 | 47 | Lafayette (243) | Final | L | -2 |
| 20 | 2022-01-26 | Lafayette (262) | 57 | 67 | Boston University (151) | Final | L | -10 |
| 21 | 2022-01-29 | Lafayette (262) | 46 | 50 | Army (233) | Final | L | -4 |
| 22 | 2022-02-01 | American (164) | 58 | 51 | Lafayette (274) | Final | L | -7 |
| 23 | 2022-02-03 | Holy Cross (145) | 59 | 50 | Lafayette (274) | Final | L | -9 |
| 24 | 2022-02-06 | Lafayette (274) | 40 | 68 | Bucknell (104) | Final | L | -28 |
| 25 | 2022-02-09 | Navy (127) | 51 | 58 | Lafayette (292) | Final | W | 7 |
| 26 | 2022-02-12 | Lehigh (116) | 76 | 52 | Lafayette (281) | Final | L | -24 |
| 27 | 2022-02-16 | Lafayette (292) | 77 | 61 | Loyola-Maryland (258) | Final | W | 16 |
| 28 | 2022-02-19 | Bucknell (110) | 68 | 60 | Lafayette (277) | Final/OT | L | -8 |
| 29 | 2022-02-23 | Boston University (152) | 52 | 58 | Lafayette (273) | Final | W | 6 |
| 30 | 2022-02-26 | Lafayette (273) | 65 | 61 | Lehigh (118) | Final | W | 4 |
| 31 | 2022-03-02 | Lafayette (254) | 48 | 62 | American (146) | Final | L | -14 |
| 32 | 2022-03-05 | Loyola-Maryland (313) | 49 | 58 | Lafayette (254) | Final | W | 9 |
| 33 | 2022-03-07 | Lafayette (254) | 48 | 54 | American (146) | Final | L | -6 |