NCAA Women's Basketball Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Loyola-Maryland (337) | 71 | 81 | Niagara (269) | Final | L | -10 |
| 2 | 2021-11-12 | George Mason (57) | 53 | 51 | Loyola-Maryland (258) | Final | L | -2 |
| 3 | 2021-11-14 | Fairleigh Dickinson (181) | 59 | 68 | Loyola-Maryland (337) | Final/OT | W | 9 |
| 4 | 2021-11-17 | UMBC (268) | 57 | 63 | Loyola-Maryland (267) | Final | W | 6 |
| 5 | 2021-11-20 | Loyola-Maryland (267) | 53 | 55 | Hofstra (269) | Final | L | -2 |
| 6 | 2021-11-24 | Loyola-Maryland (281) | 55 | 66 | Georgetown (171) | Final | L | -11 |
| 7 | 2021-12-01 | Loyola-Maryland (287) | 59 | 61 | Howard (282) | Final | L | -2 |
| 8 | 2021-12-04 | Mount St Mary's (270) | 55 | 56 | Loyola-Maryland (258) | Final | W | 1 |
| 9 | 2021-12-08 | Morgan State (217) | 64 | 55 | Loyola-Maryland (278) | Final | L | -9 |
| 10 | 2021-12-11 | Loyola-Maryland (278) | 53 | 75 | Toledo (148) | Final | L | -22 |
| 11 | 2021-12-23 | Loyola-Maryland (296) | 0 | 0 | St. Francis (NY) (253) | Cancelled | - | - |
| 12 | 2021-12-30 | Army (201) | 0 | 0 | Loyola-Maryland (297) | Postponed | - | - |
| 13 | 2022-01-02 | Loyola-Maryland (258) | 0 | 0 | Holy Cross (121) | Postponed | - | - |
| 14 | 2022-01-05 | Boston University (284) | 64 | 51 | Loyola-Maryland (258) | Final | L | -13 |
| 15 | 2022-01-08 | Loyola-Maryland (258) | 42 | 62 | Bucknell (275) | Final | L | -20 |
| 16 | 2022-01-12 | Loyola-Maryland (258) | 39 | 48 | Lafayette (292) | Final | L | -9 |
| 17 | 2022-01-15 | Lehigh (123) | 72 | 61 | Loyola-Maryland (299) | Final | L | -11 |
| 18 | 2022-01-17 | Loyola-Maryland (299) | 48 | 63 | Holy Cross (146) | Final | L | -15 |
| 19 | 2022-01-19 | Loyola-Maryland (258) | 47 | 65 | Boston University (284) | Final | L | -18 |
| 20 | 2022-01-22 | Loyola-Maryland (313) | 49 | 53 | American (159) | Final | L | -4 |
| 21 | 2022-01-26 | Colgate (338) | 61 | 62 | Loyola-Maryland (315) | Final | W | 1 |
| 22 | 2022-01-29 | Bucknell (108) | 60 | 45 | Loyola-Maryland (315) | Final | L | -15 |
| 23 | 2022-02-02 | Army (209) | 63 | 57 | Loyola-Maryland (312) | Final | L | -6 |
| 24 | 2022-02-05 | Loyola-Maryland (258) | 54 | 61 | Navy (127) | Final | L | -7 |
| 25 | 2022-02-09 | Holy Cross (121) | 58 | 49 | Loyola-Maryland (258) | Final | L | -9 |
| 26 | 2022-02-12 | Loyola-Maryland (313) | 53 | 68 | Colgate (327) | Final | L | -15 |
| 27 | 2022-02-16 | Lafayette (292) | 77 | 61 | Loyola-Maryland (258) | Final | L | -16 |
| 28 | 2022-02-19 | Loyola-Maryland (317) | 49 | 73 | Lehigh (113) | Final | L | -24 |
| 29 | 2022-02-23 | Navy (287) | 42 | 56 | Loyola-Maryland (322) | Final | W | 14 |
| 30 | 2022-02-26 | American (163) | 49 | 48 | Loyola-Maryland (322) | Final | L | -1 |
| 31 | 2022-03-02 | Loyola-Maryland (313) | 55 | 63 | Army (211) | Final | L | -8 |
| 32 | 2022-03-05 | Loyola-Maryland (313) | 49 | 58 | Lafayette (254) | Final | L | -9 |