Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-08-28 | Connecticut | 0 | Fresno State | 45 | Final | L | -45 |
| 2 | 2021-09-04 | Holy Cross | 38 | Connecticut | 28 | Final | L | -10 |
| 3 | 2021-09-11 | Purdue | 49 | Connecticut | 0 | Final | L | -49 |
| 4 | 2021-09-18 | Connecticut | 21 | Army | 52 | Final | L | -31 |
| 5 | 2021-09-25 | Wyoming | 24 | Connecticut | 22 | Final | L | -2 |
| 6 | 2021-10-02 | Connecticut | 28 | Vanderbilt | 30 | Final | L | -2 |
| 7 | 2021-10-08 | Connecticut | 0 | Massachusetts | 0 | Cancelled | - | - |
| 8 | 2021-10-09 | Connecticut | 13 | Massachusetts | 27 | Final | L | -14 |
| 9 | 2021-10-16 | Yale | 15 | Connecticut | 21 | Final | W | 6 |
| 10 | 2021-10-22 | Middle Tennessee | 44 | Connecticut | 13 | Final | L | -31 |
| 11 | 2021-11-13 | Connecticut | 7 | Clemson | 44 | Final | L | -37 |
| 12 | 2021-11-20 | Connecticut | 17 | Central Florida | 49 | Final | L | -32 |
| 13 | 2021-11-27 | Houston (20) | 45 | Connecticut (196) | 17 | Final | L | -28 |