Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Villanova | 47 | Lehigh | 3 | Final | L | -44 |
| 2 | 2021-09-11 | Lehigh | 3 | Richmond | 31 | Final | L | -28 |
| 3 | 2021-09-18 | Princeton | 32 | Lehigh | 0 | Final | L | -32 |
| 4 | 2021-09-25 | Lehigh | 3 | Colgate | 30 | Final | L | -27 |
| 5 | 2021-10-02 | Yale | 34 | Lehigh | 0 | Final | L | -34 |
| 6 | 2021-10-09 | Lehigh | 0 | Penn | 20 | Final | L | -20 |
| 7 | 2021-10-23 | Lehigh | 28 | Fordham | 35 | Final | L | -7 |
| 8 | 2021-10-30 | Holy Cross | 31 | Lehigh | 12 | Final | L | -19 |
| 9 | 2021-11-06 | Lehigh | 38 | Bucknell | 6 | Final | W | 32 |
| 10 | 2021-11-13 | Georgetown | 9 | Lehigh | 23 | Final | W | 14 |
| 11 | 2021-11-20 | Lafayette | 10 | Lehigh | 17 | Final | W | 7 |