Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-01 | South Carolina (89) | 13 | Vanderbilt (76) | 10 | Final | L | -3 |
| 2 | 2016-09-10 | Middle Tennessee | 24 | Vanderbilt | 47 | Final | W | 23 |
| 3 | 2016-09-17 | Vanderbilt (76) | 7 | Georgia Tech (78) | 38 | Final | L | -31 |
| 4 | 2016-09-24 | Vanderbilt | 31 | Western Kentucky | 30 | Final/OT | W | 1 |
| 5 | 2016-10-01 | Florida (20) | 13 | Vanderbilt (62) | 6 | Final | L | -7 |
| 6 | 2016-10-08 | Vanderbilt (68) | 13 | Kentucky (62) | 20 | Final | L | -7 |
| 7 | 2016-10-15 | Vanderbilt (82) | 17 | Georgia (50) | 16 | Final | W | 1 |
| 8 | 2016-10-22 | Tennessee State | 17 | Vanderbilt | 35 | Final | W | 18 |
| 9 | 2016-11-05 | Vanderbilt (62) | 16 | Auburn (9) | 23 | Final | L | -7 |
| 10 | 2016-11-12 | Vanderbilt (68) | 17 | Missouri (96) | 26 | Final | L | -9 |
| 11 | 2016-11-19 | Ole Miss (37) | 17 | Vanderbilt (75) | 38 | Final | W | 21 |
| 12 | 2016-11-26 | Tennessee (18) | 34 | Vanderbilt (60) | 45 | Final | W | 11 |
| 13 | 2016-12-26 | North Carolina State | 41 | Vanderbilt | 17 | Final | L | -24 |