Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Northern Illinois | 34 | Wyoming | 40 | Final/3OT | L | -6 |
| 2 | 2016-09-10 | Northern Illinois | 17 | South Florida | 48 | Final | L | -31 |
| 3 | 2016-09-17 | San Diego State | 42 | Northern Illinois | 28 | Final | L | -14 |
| 4 | 2016-09-24 | Western Illinois | 28 | Northern Illinois | 23 | Final | L | -5 |
| 5 | 2016-10-01 | Northern Illinois | 31 | Ball State | 24 | Final | W | 7 |
| 6 | 2016-10-08 | Northern Illinois | 30 | Western Michigan | 45 | Final | L | -15 |
| 7 | 2016-10-15 | Central Michigan | 34 | Northern Illinois | 28 | Final/3OT | L | -6 |
| 8 | 2016-10-22 | Buffalo | 7 | Northern Illinois | 44 | Final | W | 37 |
| 9 | 2016-11-01 | Bowling Green | 20 | Northern Illinois | 45 | Final | W | 25 |
| 10 | 2016-11-09 | Toledo | 31 | Northern Illinois | 24 | Final | L | -7 |
| 11 | 2016-11-16 | Northern Illinois | 31 | Eastern Michigan | 24 | Final/OT | W | 7 |
| 12 | 2016-11-25 | Northern Illinois | 31 | Kent State | 21 | Final | W | 10 |