Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Towson | 20 | South Florida | 56 | Final | W | 36 |
| 2 | 2016-09-10 | Northern Illinois | 17 | South Florida | 48 | Final | W | 31 |
| 3 | 2016-09-17 | South Florida | 45 | Syracuse | 20 | Final | W | 25 |
| 4 | 2016-09-24 | Florida State | 55 | South Florida | 35 | Final | L | -20 |
| 5 | 2016-10-01 | South Florida | 45 | Cincinnati | 20 | Final | W | 25 |
| 6 | 2016-10-08 | East Carolina | 22 | South Florida | 38 | Final | W | 16 |
| 7 | 2016-10-15 | Connecticut | 27 | South Florida | 42 | Final | W | 15 |
| 8 | 2016-10-21 | South Florida | 30 | Temple | 46 | Final | L | -16 |
| 9 | 2016-10-28 | Navy | 45 | South Florida | 52 | Final | W | 7 |
| 10 | 2016-11-12 | South Florida | 49 | Memphis | 42 | Final | W | 7 |
| 11 | 2016-11-19 | South Florida | 35 | SMU | 27 | Final | W | 8 |
| 12 | 2016-11-26 | Central Florida | 31 | South Florida | 48 | Final | W | 17 |
| 13 | 2016-12-29 | South Florida | 46 | South Carolina | 39 | Final/OT | W | 7 |