Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Tarleton State | 10 | Stephen F. Austin | 20 | Final | W | 10 |
| 2 | 2021-09-11 | Stephen F. Austin | 22 | Texas Tech | 28 | Final | L | -6 |
| 3 | 2021-09-18 | Mississippi Valley State | 13 | Stephen F. Austin | 58 | Final | W | 45 |
| 4 | 2021-09-25 | Lincoln (CA) | 13 | Stephen F. Austin | 61 | Final | W | 48 |
| 5 | 2021-10-02 | Sam Houston State | 21 | Stephen F. Austin | 20 | Final | L | -1 |
| 6 | 2021-10-09 | Stephen F. Austin | 24 | Jacksonville State | 28 | Final | L | -4 |
| 7 | 2021-10-23 | Stephen F. Austin | 37 | Dixie State | 20 | Final | W | 17 |
| 8 | 2021-10-30 | Abilene Christian | 27 | Stephen F. Austin | 41 | Final | W | 14 |
| 9 | 2021-11-06 | Eastern Kentucky | 17 | Stephen F. Austin | 31 | Final | W | 14 |
| 10 | 2021-11-13 | Stephen F. Austin | 27 | Central Arkansas | 14 | Final | W | 13 |
| 11 | 2021-11-20 | Stephen F. Austin | 42 | Lamar | 6 | Final | W | 36 |
| 12 | 2021-11-27 | Stephen F. Austin (147) | 28 | Incarnate Word (123) | 35 | Final(OT) | L | -7 |