Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-11 | Lamar | 0 | UTSA | 54 | Final | L | -54 |
| 2 | 2021-09-18 | Lamar | 17 | Northern Colorado | 10 | Final(OT) | W | 7 |
| 3 | 2021-09-25 | Abilene Christian | 56 | Lamar | 0 | Final | L | -56 |
| 4 | 2021-10-09 | Lamar | 7 | Sam Houston State | 41 | Final | L | -34 |
| 5 | 2021-10-16 | Lamar | 17 | Abilene Christian | 24 | Final | L | -7 |
| 6 | 2021-10-23 | Central Arkansas | 49 | Lamar | 38 | Final | L | -11 |
| 7 | 2021-10-30 | Lamar | 10 | Eastern Kentucky | 42 | Final | L | -32 |
| 8 | 2021-11-06 | Lamar | 21 | Tarleton State | 42 | Final | L | -21 |
| 9 | 2021-11-13 | Jacksonville State | 38 | Lamar | 7 | Final | L | -31 |
| 10 | 2021-11-20 | Stephen F. Austin | 42 | Lamar | 6 | Final | L | -36 |