Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-02 | Incarnate Word | 41 | Youngstown State | 44 | Final(OT) | L | -3 |
| 2 | 2021-09-11 | Prairie View A&M | 9 | Incarnate Word | 40 | Final | W | 31 |
| 3 | 2021-09-18 | Incarnate Word | 42 | Texas State | 34 | Final | W | 8 |
| 4 | 2021-09-25 | McNeese State | 0 | Incarnate Word | 31 | Final | W | 31 |
| 5 | 2021-10-02 | Incarnate Word | 38 | Northwestern State | 27 | Final | W | 11 |
| 6 | 2021-10-16 | Nicholls State | 21 | Incarnate Word | 38 | Final | W | 17 |
| 7 | 2021-10-23 | Incarnate Word | 20 | McNeese State | 28 | Final | L | -8 |
| 8 | 2021-10-30 | Houston Baptist | 21 | Incarnate Word | 49 | Final | W | 28 |
| 9 | 2021-11-06 | Southeastern Louisiana | 52 | Incarnate Word | 55 | Final | W | 3 |
| 10 | 2021-11-13 | Incarnate Word | 27 | Nicholls State | 23 | Final | W | 4 |
| 11 | 2021-11-20 | Incarnate Word | 55 | Houston Baptist | 14 | Final | W | 41 |
| 12 | 2021-11-27 | Stephen F. Austin (147) | 28 | Incarnate Word (123) | 35 | Final(OT) | W | 7 |
| 13 | 2021-12-04 | Incarnate Word (128) | 42 | Sam Houston State (76) | 49 | Final | L | -7 |