Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-02 | Sam Houston State | 42 | Northern Arizona | 16 | Final | W | 26 |
| 2 | 2021-09-11 | Southeast Missouri State | 14 | Sam Houston State | 52 | Final | W | 38 |
| 3 | 2021-09-25 | Sam Houston State | 45 | Central Arkansas | 35 | Final | W | 10 |
| 4 | 2021-10-02 | Sam Houston State | 21 | Stephen F. Austin | 20 | Final | W | 1 |
| 5 | 2021-10-09 | Lamar | 7 | Sam Houston State | 41 | Final | W | 34 |
| 6 | 2021-10-23 | Jacksonville State | 7 | Sam Houston State | 42 | Final | W | 35 |
| 7 | 2021-10-30 | Sam Houston State | 45 | Tarleton State | 27 | Final | W | 18 |
| 8 | 2021-11-06 | Dixie State | 10 | Sam Houston State | 59 | Final | W | 49 |
| 9 | 2021-11-13 | Eastern Kentucky | 28 | Sam Houston State | 42 | Final | W | 14 |
| 10 | 2021-11-20 | Sam Houston State | 35 | Abilene Christian | 9 | Final | W | 26 |
| 11 | 2021-12-04 | Incarnate Word (128) | 42 | Sam Houston State (76) | 49 | Final | W | 7 |
| 12 | 2021-12-11 | Montana State (109) | 42 | Sam Houston State (76) | 19 | Final | L | -23 |