Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Abilene Christian | 9 | SMU | 56 | Final | L | -47 |
| 2 | 2021-09-11 | Louisiana College | 7 | Abilene Christian | 62 | Final | W | 55 |
| 3 | 2021-09-18 | UT Permian Basin | 9 | Abilene Christian | 34 | Final | W | 25 |
| 4 | 2021-09-25 | Abilene Christian | 56 | Lamar | 0 | Final | W | 56 |
| 5 | 2021-10-02 | Central Arkansas | 42 | Abilene Christian | 21 | Final | L | -21 |
| 6 | 2021-10-09 | Abilene Christian | 15 | Eastern Kentucky | 30 | Final | L | -15 |
| 7 | 2021-10-16 | Lamar | 17 | Abilene Christian | 24 | Final | W | 7 |
| 8 | 2021-10-30 | Abilene Christian | 27 | Stephen F. Austin | 41 | Final | L | -14 |
| 9 | 2021-11-06 | Abilene Christian | 25 | Jacksonville State | 40 | Final | L | -15 |
| 10 | 2021-11-13 | Tarleton State | 3 | Abilene Christian | 29 | Final | W | 26 |
| 11 | 2021-11-20 | Sam Houston State | 35 | Abilene Christian | 9 | Final | L | -26 |