Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Sacramento State | 19 | Dixie State | 7 | Final | L | -12 |
| 2 | 2021-09-11 | Weber State | 41 | Dixie State | 3 | Final | L | -38 |
| 3 | 2021-09-18 | Dixie State | 27 | UC-Davis | 60 | Final | L | -33 |
| 4 | 2021-10-02 | Dixie State | 7 | South Dakota State | 55 | Final | L | -48 |
| 5 | 2021-10-09 | Dixie State | 14 | Montana | 31 | Final | L | -17 |
| 6 | 2021-10-16 | Tarleton State | 41 | Dixie State | 20 | Final | L | -21 |
| 7 | 2021-10-23 | Stephen F. Austin | 37 | Dixie State | 20 | Final | L | -17 |
| 8 | 2021-10-30 | Dixie State | 10 | Delaware | 17 | Final | L | -7 |
| 9 | 2021-11-06 | Dixie State | 10 | Sam Houston State | 59 | Final | L | -49 |
| 10 | 2021-11-13 | Fort Lewis | 21 | Dixie State | 62 | Final | W | 41 |
| 11 | 2021-11-20 | Missouri State | 55 | Dixie State | 24 | Final | L | -31 |