Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-01 | UAB | 31 | Jacksonville State | 0 | Final | L | -31 |
| 2 | 2021-09-11 | Jacksonville State | 20 | Florida State | 17 | Final | W | 3 |
| 3 | 2021-09-18 | North Alabama | 24 | Jacksonville State | 27 | Final | W | 3 |
| 4 | 2021-09-25 | Tennessee-Martin | 34 | Jacksonville State | 31 | Final | L | -3 |
| 5 | 2021-10-02 | Jacksonville State | 6 | Kennesaw State | 31 | Final | L | -25 |
| 6 | 2021-10-09 | Stephen F. Austin | 24 | Jacksonville State | 28 | Final | W | 4 |
| 7 | 2021-10-23 | Jacksonville State | 7 | Sam Houston State | 42 | Final | L | -35 |
| 8 | 2021-10-30 | Central Arkansas | 38 | Jacksonville State | 14 | Final | L | -24 |
| 9 | 2021-11-06 | Abilene Christian | 25 | Jacksonville State | 40 | Final | W | 15 |
| 10 | 2021-11-13 | Jacksonville State | 38 | Lamar | 7 | Final | W | 31 |
| 11 | 2021-11-20 | Jacksonville State | 31 | Eastern Kentucky | 39 | Final(OT) | L | -8 |