Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Tarleton State | 10 | Stephen F. Austin | 20 | Final | L | -10 |
| 2 | 2021-09-11 | Fort Lewis | 7 | Tarleton State | 54 | Final | W | 47 |
| 3 | 2021-09-18 | Southern Utah | 40 | Tarleton State | 35 | Final | L | -5 |
| 4 | 2021-09-25 | New Mexico Highlands | 21 | Tarleton State | 40 | Final | W | 19 |
| 5 | 2021-10-02 | Tarleton State | 3 | Eastern Kentucky | 20 | Final | L | -17 |
| 6 | 2021-10-16 | Tarleton State | 41 | Dixie State | 20 | Final | W | 21 |
| 7 | 2021-10-23 | Midwestern State | 14 | Tarleton State | 17 | Final | W | 3 |
| 8 | 2021-10-30 | Sam Houston State | 45 | Tarleton State | 27 | Final | L | -18 |
| 9 | 2021-11-06 | Lamar | 21 | Tarleton State | 42 | Final | W | 21 |
| 10 | 2021-11-13 | Tarleton State | 3 | Abilene Christian | 29 | Final | L | -26 |
| 11 | 2021-11-20 | Central Arkansas | 3 | Tarleton State | 24 | Final | W | 21 |