Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Boise State | 45 | Louisiana | 10 | Final | L | -35 |
| 2 | 2016-09-10 | McNeese State | 22 | Louisiana | 30 | Final | W | 8 |
| 3 | 2016-09-17 | South Alabama | 23 | Louisiana | 28 | Final | W | 5 |
| 4 | 2016-09-24 | Louisiana | 39 | Tulane | 41 | Final/4OT | L | -2 |
| 5 | 2016-10-01 | Louisiana | 31 | New Mexico State | 37 | Final/2OT | L | -6 |
| 6 | 2016-10-12 | Appalachian State | 24 | Louisiana | 0 | Final | L | -24 |
| 7 | 2016-10-22 | Louisiana | 27 | Texas State | 3 | Final | W | 24 |
| 8 | 2016-11-05 | Idaho | 23 | Louisiana | 13 | Final | L | -10 |
| 9 | 2016-11-10 | Louisiana | 33 | Georgia Southern | 26 | Final | W | 7 |
| 10 | 2016-11-19 | Louisiana | 21 | Georgia | 35 | Final | L | -14 |
| 11 | 2016-11-26 | Arkansas State | 19 | Louisiana | 24 | Final | W | 5 |
| 12 | 2016-12-03 | Louisiana | 30 | Louisiana-Monroe | 3 | Final | W | 27 |
| 13 | 2016-12-17 | Southern Miss | 28 | Louisiana | 21 | Final | L | -7 |