Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | SMU (113) | 34 | North Texas (127) | 21 | Final | W | 13 |
| 2 | 2016-09-10 | SMU (113) | 13 | Baylor (16) | 40 | Final | L | -27 |
| 3 | 2016-09-17 | Liberty | 14 | SMU | 29 | Final | W | 15 |
| 4 | 2016-09-23 | TCU (71) | 33 | SMU (61) | 3 | Final | L | -30 |
| 5 | 2016-10-01 | SMU (84) | 20 | Temple (86) | 45 | Final | L | -25 |
| 6 | 2016-10-07 | SMU (102) | 40 | Tulsa (52) | 43 | Final/OT | L | -3 |
| 7 | 2016-10-22 | Houston (13) | 16 | SMU (103) | 38 | Final | W | 22 |
| 8 | 2016-10-29 | SMU (74) | 35 | Tulane (86) | 31 | Final | W | 4 |
| 9 | 2016-11-05 | Memphis (53) | 51 | SMU (73) | 7 | Final | L | -44 |
| 10 | 2016-11-12 | SMU (82) | 55 | East Carolina (94) | 31 | Final | W | 24 |
| 11 | 2016-11-19 | South Florida | 35 | SMU | 27 | Final | L | -8 |
| 12 | 2016-11-26 | Navy (26) | 75 | SMU (76) | 31 | Final | L | -44 |