Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-01 | Missouri State (124) | 27 | Central Arkansas (185) | 14 | Final | W | 13 |
| 2 | 2022-09-08 | Tennessee-Martin (142) | 30 | Missouri State (124) | 35 | Final | W | 5 |
| 3 | 2022-09-17 | Missouri State (149) | 27 | Arkansas (23) | 38 | Final | L | -11 |
| 4 | 2022-09-24 | South Dakota State (139) | 28 | Missouri State (166) | 14 | Final | L | -14 |
| 5 | 2022-10-01 | Missouri State (172) | 31 | North Dakota (159) | 48 | Final | L | -17 |
| 6 | 2022-10-08 | Southern Illinois (129) | 38 | Missouri State (179) | 21 | Final | L | -17 |
| 7 | 2022-10-22 | Missouri State (190) | 20 | Northern Iowa (173) | 41 | Final | L | -21 |
| 8 | 2022-10-29 | Western Illinois (253) | 14 | Missouri State (183) | 64 | Final | W | 50 |
| 9 | 2022-11-05 | Missouri State (191) | 13 | South Dakota (189) | 20 | Final | L | -7 |
| 10 | 2022-11-12 | Youngstown State (171) | 22 | Missouri State (180) | 25 | Final | W | 3 |
| 11 | 2022-11-19 | Missouri State (178) | 24 | Indiana State (231) | 7 | Final | W | 17 |