Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-01 | Cal Poly (228) | 7 | Fresno State (32) | 35 | Final | L | -28 |
| 2 | 2022-09-10 | San Diego (194) | 27 | Cal Poly (228) | 28 | Final | W | 1 |
| 3 | 2022-09-17 | Cal Poly (210) | 21 | South Dakota (184) | 38 | Final | L | -17 |
| 4 | 2022-10-01 | Sacramento State (96) | 49 | Cal Poly (219) | 21 | Final | L | -28 |
| 5 | 2022-10-08 | Cal Poly (227) | 29 | Northern Arizona (197) | 31 | Final | L | -2 |
| 6 | 2022-10-15 | Cal Poly (240) | 31 | Idaho State (231) | 40 | Final | L | -9 |
| 7 | 2022-10-22 | Eastern Washington (197) | 17 | Cal Poly (244) | 10 | Final | L | -7 |
| 8 | 2022-10-29 | Cal Poly (241) | 17 | UC-Davis | 59 | Final | L | -42 |
| 9 | 2022-11-05 | Cal Poly (248) | 0 | Montana (142) | 57 | Final | L | -57 |
| 10 | 2022-11-12 | Montana State (122) | 72 | Cal Poly (248) | 28 | Final | L | -44 |
| 11 | 2022-11-19 | Portland State (201) | 42 | Cal Poly (240) | 49 | Final | W | 7 |