Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-03 | St. Thomas (FL) | 26 | Butler (252) | 31 | Final | W | 5 |
| 2 | 2022-09-10 | Taylor | 10 | Butler (252) | 45 | Final | W | 35 |
| 3 | 2022-09-17 | Butler (214) | 17 | South Dakota State (141) | 45 | Final | L | -28 |
| 4 | 2022-10-01 | Butler (229) | 0 | Davidson (176) | 31 | Final | L | -31 |
| 5 | 2022-10-08 | Dayton (229) | 0 | Butler (214) | 31 | Final | W | 31 |
| 6 | 2022-10-15 | Butler (200) | 26 | Valparaiso (225) | 25 | Final | W | 1 |
| 7 | 2022-10-22 | Marist (252) | 10 | Butler (194) | 31 | Final | W | 21 |
| 8 | 2022-10-29 | Morehead State (255) | 20 | Butler (184) | 56 | Final | W | 36 |
| 9 | 2022-11-05 | Butler (183) | 26 | San Diego (256) | 23 | Final | W | 3 |
| 10 | 2022-11-12 | Butler (201) | 24 | Drake (255) | 27 | Final | L | -3 |
| 11 | 2022-11-19 | St. Thomas (172) | 27 | Butler (205) | 13 | Final | L | -14 |