Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-02 | Holy Cross (139) | 31 | Merrimack (229) | 17 | Final | W | 14 |
| 2 | 2022-09-10 | Holy Cross (139) | 37 | Buffalo (121) | 31 | Final | W | 6 |
| 3 | 2022-09-17 | Yale (202) | 14 | Holy Cross (107) | 38 | Final | W | 24 |
| 4 | 2022-09-24 | Holy Cross (93) | 35 | Colgate (195) | 10 | Final | W | 25 |
| 5 | 2022-10-01 | Holy Cross (89) | 30 | Harvard (186) | 21 | Final | W | 9 |
| 6 | 2022-10-08 | Bucknell (255) | 0 | Holy Cross (76) | 57 | Final | W | 57 |
| 7 | 2022-10-22 | Holy Cross (79) | 24 | Lafayette (179) | 21 | Final | W | 3 |
| 8 | 2022-10-29 | Fordham (155) | 52 | Holy Cross (72) | 53 | Final(OT) | W | 1 |
| 9 | 2022-11-05 | Lehigh (242) | 14 | Holy Cross (74) | 42 | Final | W | 28 |
| 10 | 2022-11-12 | Bryant (213) | 29 | Holy Cross (73) | 36 | Final | W | 7 |
| 11 | 2022-11-19 | Holy Cross (74) | 47 | Georgetown (243) | 10 | Final | W | 37 |
| 12 | 2022-12-03 | New Hampshire (141) | 19 | Holy Cross (71) | 35 | Final | W | 16 |
| 13 | 2022-12-10 | Holy Cross (71) | 21 | South Dakota State (91) | 42 | Final | L | -21 |