Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-02 | Cal Poly | 27 | Nevada | 30 | Final/OT | L | -3 |
| 2 | 2016-09-10 | San Diego | 16 | Cal Poly | 38 | Final | W | 22 |
| 3 | 2016-09-17 | Cal Poly | 38 | South Dakota State | 31 | Final | W | 7 |
| 4 | 2016-09-24 | Montana | 41 | Cal Poly | 42 | Final | W | 1 |
| 5 | 2016-10-01 | Cal Poly | 24 | North Dakota | 31 | Final | L | -7 |
| 6 | 2016-10-15 | Cal Poly | 55 | Portland State | 35 | Final | W | 20 |
| 7 | 2016-10-22 | UC-Davis | 16 | Cal Poly | 21 | Final | W | 5 |
| 8 | 2016-10-29 | Cal Poly | 59 | Sacramento State | 47 | Final | W | 12 |
| 9 | 2016-11-05 | Eastern Washington | 42 | Cal Poly | 21 | Final | L | -21 |
| 10 | 2016-11-12 | Cal Poly (139) | 15 | Weber State (180) | 22 | Final | L | -7 |
| 11 | 2016-11-19 | Northern Colorado | 48 | Cal Poly | 55 | Final | W | 7 |
| 12 | 2016-11-26 | San Diego (145) | 35 | Cal Poly (147) | 21 | Final | L | -14 |