Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2016-09-03 | Quincy | 38 | Drake | 35 | Final | L | -3 |
| 2 | 2016-09-10 | Drake | 28 | South Dakota State | 56 | Final | L | -28 |
| 3 | 2016-09-17 | McKendree | 16 | Drake | 28 | Final | W | 12 |
| 4 | 2016-09-24 | Morehead State | 28 | Drake | 30 | Final | W | 2 |
| 5 | 2016-10-01 | Drake | 10 | Dayton | 35 | Final | L | -25 |
| 6 | 2016-10-08 | Drake | 35 | Valparaiso | 21 | Final | W | 14 |
| 7 | 2016-10-15 | San Diego | 38 | Drake | 7 | Final | L | -31 |
| 8 | 2016-10-29 | Campbell (228) | 21 | Drake (234) | 33 | Final | W | 12 |
| 9 | 2016-11-05 | Drake (226) | 31 | Jacksonville (200) | 27 | Final | W | 4 |
| 10 | 2016-11-12 | Butler (239) | 14 | Drake (214) | 28 | Final | W | 14 |
| 11 | 2016-11-19 | Drake (203) | 45 | Stetson (229) | 17 | Final | W | 28 |