Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-02 | Sam Houston State | 42 | Northern Arizona | 16 | Final | L | -26 |
| 2 | 2021-09-11 | Northern Arizona | 7 | South Dakota | 34 | Final | L | -27 |
| 3 | 2021-09-18 | Northern Arizona | 21 | Arizona | 19 | Final | W | 2 |
| 4 | 2021-09-25 | Northern Arizona | 10 | Northern Colorado | 17 | Final/OT | L | -7 |
| 5 | 2021-10-02 | Idaho State | 17 | Northern Arizona | 48 | Final | W | 31 |
| 6 | 2021-10-16 | Southern Utah | 35 | Northern Arizona | 59 | Final | W | 24 |
| 7 | 2021-10-23 | Northern Arizona | 0 | Sacramento State | 44 | Final | L | -44 |
| 8 | 2021-10-30 | Northern Arizona | 38 | Idaho | 31 | Final | W | 7 |
| 9 | 2021-11-06 | UC-Davis | 40 | Northern Arizona | 24 | Final | L | -16 |
| 10 | 2021-11-13 | Montana | 30 | Northern Arizona | 3 | Final | L | -27 |
| 11 | 2021-11-20 | Northern Arizona | 45 | Cal Poly | 21 | Final | W | 24 |