Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Bucknell | 0 | Sacred Heart | 21 | Final | W | 21 |
| 2 | 2021-09-11 | Sacred Heart | 6 | Bryant | 17 | Final | L | -11 |
| 3 | 2021-09-18 | Morgan State | 7 | Sacred Heart | 21 | Final | W | 14 |
| 4 | 2021-09-25 | Sacred Heart | 3 | Dartmouth | 41 | Final | L | -38 |
| 5 | 2021-10-02 | Sacred Heart | 17 | Howard | 22 | Final | L | -5 |
| 6 | 2021-10-09 | Merrimack | 10 | Sacred Heart | 20 | Final | W | 10 |
| 7 | 2021-10-16 | Central Connecticut State | 17 | Sacred Heart | 27 | Final | W | 10 |
| 8 | 2021-10-23 | Duquesne | 13 | Sacred Heart | 31 | Final | W | 18 |
| 9 | 2021-11-13 | Wagner | 0 | Sacred Heart | 27 | Final | W | 27 |
| 10 | 2021-11-20 | Sacred Heart | 38 | Long Island | 14 | Final | W | 24 |
| 11 | 2021-11-27 | Sacred Heart (191) | 10 | Holy Cross (131) | 13 | Final | L | -3 |