Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-02 | Wagner | 7 | Buffalo | 69 | Final | L | -62 |
| 2 | 2021-09-11 | Central Connecticut State | 21 | Wagner | 19 | Final | L | -2 |
| 3 | 2021-09-25 | Wagner | 7 | Temple | 41 | Final | L | -34 |
| 4 | 2021-10-02 | Delaware State | 33 | Wagner | 27 | Final(OT) | L | -6 |
| 5 | 2021-10-09 | Wagner | 7 | Fordham | 56 | Final | L | -49 |
| 6 | 2021-10-23 | Bryant | 31 | Wagner | 10 | Final | L | -21 |
| 7 | 2021-10-30 | Wagner | 14 | Long Island | 28 | Final | L | -14 |
| 8 | 2021-11-06 | Merrimack | 35 | Wagner | 26 | Final | L | -9 |
| 9 | 2021-11-13 | Wagner | 0 | Sacred Heart | 27 | Final | L | -27 |
| 10 | 2021-11-20 | Duquesne | 44 | Wagner | 0 | Final | L | -44 |