Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Duquesne | 3 | TCU | 45 | Final | L | -42 |
| 2 | 2021-09-11 | Duquesne | 28 | Ohio | 26 | Final | W | 2 |
| 3 | 2021-09-25 | Virginia Lynchburg | 7 | Duquesne | 56 | Final | W | 49 |
| 4 | 2021-10-02 | Duquesne | 37 | Merrimack | 14 | Final | W | 23 |
| 5 | 2021-10-09 | Bryant | 34 | Duquesne | 39 | Final | W | 5 |
| 6 | 2021-10-23 | Duquesne | 13 | Sacred Heart | 31 | Final | L | -18 |
| 7 | 2021-11-06 | Duquesne | 34 | Long Island | 28 | Final | W | 6 |
| 8 | 2021-11-13 | Central Connecticut State | 27 | Duquesne | 31 | Final | W | 4 |
| 9 | 2021-11-20 | Duquesne | 44 | Wagner | 0 | Final | W | 44 |