Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | St. Anselm | 23 | Merrimack | 55 | Final | W | 32 |
| 2 | 2021-09-11 | Merrimack | 35 | Holy Cross | 21 | Final | W | 14 |
| 3 | 2021-09-18 | Merrimack | 26 | Maine | 31 | Final | L | -5 |
| 4 | 2021-09-25 | Merrimack | 47 | Delaware State | 10 | Final | W | 37 |
| 5 | 2021-10-02 | Duquesne | 37 | Merrimack | 14 | Final | L | -23 |
| 6 | 2021-10-09 | Merrimack | 10 | Sacred Heart | 20 | Final | L | -10 |
| 7 | 2021-10-16 | Merrimack | 43 | Long Island | 5 | Final | W | 38 |
| 8 | 2021-10-30 | Central Connecticut State | 49 | Merrimack | 21 | Final | L | -28 |
| 9 | 2021-11-06 | Merrimack | 35 | Wagner | 26 | Final | W | 9 |
| 10 | 2021-11-20 | Bryant | 58 | Merrimack | 14 | Final | L | -44 |