Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Bucknell | 0 | Sacred Heart | 21 | Final | L | -21 |
| 2 | 2021-09-11 | Bucknell | 3 | Villanova | 55 | Final | L | -52 |
| 3 | 2021-09-18 | Penn | 30 | Bucknell | 6 | Final | L | -24 |
| 4 | 2021-10-02 | Cornell | 10 | Bucknell | 21 | Final | W | 11 |
| 5 | 2021-10-09 | Bucknell | 0 | Lafayette | 27 | Final | L | -27 |
| 6 | 2021-10-16 | Bucknell | 21 | Fordham | 66 | Final | L | -45 |
| 7 | 2021-10-23 | Georgetown | 29 | Bucknell | 21 | Final | L | -8 |
| 8 | 2021-10-30 | Bucknell | 10 | Colgate | 33 | Final | L | -23 |
| 9 | 2021-11-06 | Lehigh | 38 | Bucknell | 6 | Final | L | -32 |
| 10 | 2021-11-13 | Bucknell | 10 | Army | 63 | Final | L | -53 |
| 11 | 2021-11-20 | Holy Cross | 45 | Bucknell | 6 | Final | L | -39 |