Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Howard | 14 | Richmond | 38 | Final | L | -24 |
| 2 | 2021-09-11 | Howard | 0 | Maryland | 62 | Final | L | -62 |
| 3 | 2021-09-18 | Hampton | 48 | Howard | 32 | Final | L | -16 |
| 4 | 2021-09-25 | Howard | 16 | Robert Morris | 22 | Final | L | -6 |
| 5 | 2021-10-02 | Sacred Heart | 17 | Howard | 22 | Final | W | 5 |
| 6 | 2021-10-08 | Morgan State | 0 | Howard | 27 | Final | W | 27 |
| 7 | 2021-10-23 | Norfolk State | 45 | Howard | 31 | Final | L | -14 |
| 8 | 2021-10-30 | Howard | 23 | Delaware State | 30 | Final | L | -7 |
| 9 | 2021-11-06 | Howard | 12 | South Carolina State | 15 | Final | L | -3 |
| 10 | 2021-11-13 | North Carolina Central | 45 | Howard | 27 | Final | L | -18 |
| 11 | 2021-11-20 | Virginia Lynchburg | 6 | Howard | 56 | Final | W | 50 |