Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Towson | 31 | Morgan State | 0 | Final | L | -31 |
| 2 | 2021-09-11 | Morgan State | 20 | Tulane | 69 | Final | L | -49 |
| 3 | 2021-09-18 | Morgan State | 7 | Sacred Heart | 21 | Final | L | -14 |
| 4 | 2021-10-08 | Morgan State | 0 | Howard | 27 | Final | L | -27 |
| 5 | 2021-10-16 | Morgan State | 14 | South Carolina State | 37 | Final | L | -23 |
| 6 | 2021-10-23 | North Carolina Central | 28 | Morgan State | 17 | Final | L | -11 |
| 7 | 2021-10-30 | Morgan State | 20 | Norfolk State | 31 | Final | L | -11 |
| 8 | 2021-11-04 | Delaware State | 14 | Morgan State | 20 | Final | W | 6 |
| 9 | 2021-11-13 | Morgan State | 14 | Albany | 41 | Final | L | -27 |
| 10 | 2021-11-20 | Georgetown | 21 | Morgan State | 28 | Final | W | 7 |