Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Penn State | 16 | Wisconsin | 10 | Final | W | 6 |
| 2 | 2021-09-11 | Ball State | 13 | Penn State | 44 | Final | W | 31 |
| 3 | 2021-09-18 | Auburn | 20 | Penn State | 28 | Final | W | 8 |
| 4 | 2021-09-25 | Villanova | 17 | Penn State | 38 | Final | W | 21 |
| 5 | 2021-10-02 | Indiana | 0 | Penn State | 24 | Final | W | 24 |
| 6 | 2021-10-09 | Penn State | 20 | Iowa | 23 | Final | L | -3 |
| 7 | 2021-10-23 | Illinois | 20 | Penn State | 18 | Final(OT) | L | -2 |
| 8 | 2021-10-30 | Penn State | 24 | Ohio State | 33 | Final | L | -9 |
| 9 | 2021-11-06 | Penn State | 31 | Maryland | 14 | Final | W | 17 |
| 10 | 2021-11-13 | Michigan | 21 | Penn State | 17 | Final | L | -4 |
| 11 | 2021-11-20 | Rutgers | 0 | Penn State | 28 | Final | W | 28 |
| 12 | 2021-11-27 | Penn State (28) | 27 | Michigan State (9) | 30 | Final | L | -3 |
| 13 | 2022-01-01 | Penn State (31) | 10 | Arkansas (20) | 24 | Final | L | -14 |