Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-02 | Western Illinois | 21 | Ball State | 31 | Final | W | 10 |
| 2 | 2021-09-11 | Ball State | 13 | Penn State | 44 | Final | L | -31 |
| 3 | 2021-09-18 | Ball State | 12 | Wyoming | 45 | Final | L | -33 |
| 4 | 2021-09-25 | Toledo | 22 | Ball State | 12 | Final | L | -10 |
| 5 | 2021-10-02 | Army | 16 | Ball State | 28 | Final | W | 12 |
| 6 | 2021-10-09 | Ball State | 45 | Western Michigan | 20 | Final | W | 25 |
| 7 | 2021-10-16 | Ball State | 38 | Eastern Michigan | 31 | Final | W | 7 |
| 8 | 2021-10-23 | Miami (OH) | 24 | Ball State | 17 | Final | L | -7 |
| 9 | 2021-11-02 | Ball State | 31 | Akron | 25 | Final | W | 6 |
| 10 | 2021-11-10 | Ball State | 29 | Northern Illinois | 30 | Final | L | -1 |
| 11 | 2021-11-17 | Central Michigan | 37 | Ball State | 17 | Final | L | -20 |
| 12 | 2021-11-23 | Buffalo (120) | 3 | Ball State (87) | 20 | Final | W | 17 |
| 13 | 2021-12-25 | Georgia State (64) | 51 | Ball State (91) | 20 | Final | L | -31 |