Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-08-28 | Nebraska | 22 | Illinois | 30 | Final | W | 8 |
| 2 | 2021-09-04 | UTSA | 37 | Illinois | 30 | Final | L | -7 |
| 3 | 2021-09-11 | Illinois | 14 | Virginia | 42 | Final | L | -28 |
| 4 | 2021-09-17 | Maryland | 20 | Illinois | 17 | Final | L | -3 |
| 5 | 2021-09-25 | Illinois | 9 | Purdue | 13 | Final | L | -4 |
| 6 | 2021-10-02 | Charlotte | 14 | Illinois | 24 | Final | W | 10 |
| 7 | 2021-10-09 | Wisconsin | 24 | Illinois | 0 | Final | L | -24 |
| 8 | 2021-10-23 | Illinois | 20 | Penn State | 18 | Final(OT) | W | 2 |
| 9 | 2021-10-30 | Rutgers | 20 | Illinois | 14 | Final | L | -6 |
| 10 | 2021-11-06 | Illinois | 14 | Minnesota | 6 | Final | W | 8 |
| 11 | 2021-11-20 | Illinois | 23 | Iowa | 33 | Final | L | -10 |
| 12 | 2021-11-27 | Northwestern (110) | 14 | Illinois (65) | 47 | Final | W | 33 |