Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Akron | 10 | Auburn | 60 | Final | W | 50 |
| 2 | 2021-09-11 | Alabama State | 0 | Auburn | 62 | Final | W | 62 |
| 3 | 2021-09-18 | Auburn | 20 | Penn State | 28 | Final | L | -8 |
| 4 | 2021-09-25 | Georgia State | 24 | Auburn | 34 | Final | W | 10 |
| 5 | 2021-10-02 | Auburn | 24 | LSU | 19 | Final | W | 5 |
| 6 | 2021-10-09 | Georgia | 34 | Auburn | 10 | Final | L | -24 |
| 7 | 2021-10-16 | Auburn | 38 | Arkansas | 23 | Final | W | 15 |
| 8 | 2021-10-30 | Ole Miss | 20 | Auburn | 31 | Final | W | 11 |
| 9 | 2021-11-06 | Auburn | 3 | Texas A&M | 20 | Final | L | -17 |
| 10 | 2021-11-13 | Mississippi State | 43 | Auburn | 34 | Final | L | -9 |
| 11 | 2021-11-20 | Auburn | 17 | South Carolina | 21 | Final | L | -4 |
| 12 | 2021-11-27 | Alabama (6) | 24 | Auburn (40) | 22 | Final(OT) | L | -2 |
| 13 | 2021-12-28 | Houston (17) | 17 | Auburn (43) | 13 | Final | L | -4 |