Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Rice | 17 | Arkansas | 38 | Final | W | 21 |
| 2 | 2021-09-11 | Texas | 21 | Arkansas | 40 | Final | W | 19 |
| 3 | 2021-09-18 | Georgia Southern | 10 | Arkansas | 45 | Final | W | 35 |
| 4 | 2021-09-25 | Texas A&M | 10 | Arkansas | 20 | Final | W | 10 |
| 5 | 2021-10-02 | Arkansas | 0 | Georgia | 37 | Final | L | -37 |
| 6 | 2021-10-09 | Arkansas | 51 | Ole Miss | 52 | Final | L | -1 |
| 7 | 2021-10-16 | Auburn | 38 | Arkansas | 23 | Final | L | -15 |
| 8 | 2021-10-23 | Arkansas-Pine Bluff | 3 | Arkansas | 45 | Final | W | 42 |
| 9 | 2021-11-06 | Mississippi State | 28 | Arkansas | 31 | Final | W | 3 |
| 10 | 2021-11-13 | Arkansas | 16 | LSU | 13 | Final(OT) | W | 3 |
| 11 | 2021-11-20 | Arkansas | 35 | Alabama | 42 | Final | L | -7 |
| 12 | 2021-11-26 | Missouri (69) | 17 | Arkansas (26) | 34 | Final | W | 17 |
| 13 | 2022-01-01 | Penn State (31) | 10 | Arkansas (20) | 24 | Final | W | 14 |