Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | West Virginia | 24 | Maryland | 30 | Final | W | 6 |
| 2 | 2021-09-11 | Howard | 0 | Maryland | 62 | Final | W | 62 |
| 3 | 2021-09-17 | Maryland | 20 | Illinois | 17 | Final | W | 3 |
| 4 | 2021-09-25 | Kent State | 16 | Maryland | 37 | Final | W | 21 |
| 5 | 2021-10-01 | Iowa | 51 | Maryland | 14 | Final | L | -37 |
| 6 | 2021-10-09 | Maryland | 17 | Ohio State | 66 | Final | L | -49 |
| 7 | 2021-10-23 | Maryland | 16 | Minnesota | 34 | Final | L | -18 |
| 8 | 2021-10-30 | Indiana | 35 | Maryland | 38 | Final | W | 3 |
| 9 | 2021-11-06 | Penn State | 31 | Maryland | 14 | Final | L | -17 |
| 10 | 2021-11-13 | Maryland | 21 | Michigan State | 40 | Final | L | -19 |
| 11 | 2021-11-20 | Michigan | 59 | Maryland | 18 | Final | L | -41 |
| 12 | 2021-11-27 | Maryland (50) | 40 | Rutgers (79) | 16 | Final | W | 24 |
| 13 | 2021-12-29 | Maryland (48) | 54 | Virginia Tech (76) | 10 | Final | W | 44 |