Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Temple | 14 | Rutgers | 61 | Final | W | 47 |
| 2 | 2021-09-11 | Rutgers | 17 | Syracuse | 7 | Final | W | 10 |
| 3 | 2021-09-18 | Delaware | 13 | Rutgers | 45 | Final | W | 32 |
| 4 | 2021-09-25 | Rutgers | 13 | Michigan | 20 | Final | L | -7 |
| 5 | 2021-10-02 | Ohio State | 52 | Rutgers | 13 | Final | L | -39 |
| 6 | 2021-10-09 | Michigan State | 31 | Rutgers | 13 | Final | L | -18 |
| 7 | 2021-10-16 | Rutgers | 7 | Northwestern | 21 | Final | L | -14 |
| 8 | 2021-10-30 | Rutgers | 20 | Illinois | 14 | Final | W | 6 |
| 9 | 2021-11-06 | Wisconsin | 52 | Rutgers | 3 | Final | L | -49 |
| 10 | 2021-11-13 | Rutgers | 38 | Indiana | 3 | Final | W | 35 |
| 11 | 2021-11-20 | Rutgers | 0 | Penn State | 28 | Final | L | -28 |
| 12 | 2021-11-27 | Maryland (50) | 40 | Rutgers (79) | 16 | Final | L | -24 |
| 13 | 2021-12-31 | Wake Forest (20) | 38 | Rutgers (29) | 10 | Final | L | -28 |