Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Penn State | 16 | Wisconsin | 10 | Final | L | -6 |
| 2 | 2021-09-11 | Eastern Michigan | 7 | Wisconsin | 34 | Final | W | 27 |
| 3 | 2021-09-25 | Notre Dame | 41 | Wisconsin | 13 | Final | L | -28 |
| 4 | 2021-10-02 | Michigan | 38 | Wisconsin | 17 | Final | L | -21 |
| 5 | 2021-10-09 | Wisconsin | 24 | Illinois | 0 | Final | W | 24 |
| 6 | 2021-10-16 | Army | 14 | Wisconsin | 20 | Final | W | 6 |
| 7 | 2021-10-23 | Wisconsin | 30 | Purdue | 13 | Final | W | 17 |
| 8 | 2021-10-30 | Iowa | 7 | Wisconsin | 27 | Final | W | 20 |
| 9 | 2021-11-06 | Wisconsin | 52 | Rutgers | 3 | Final | W | 49 |
| 10 | 2021-11-13 | Northwestern | 7 | Wisconsin | 35 | Final | W | 28 |
| 11 | 2021-11-20 | Nebraska | 28 | Wisconsin | 35 | Final | W | 7 |
| 12 | 2021-11-27 | Wisconsin (14) | 13 | Minnesota (31) | 23 | Final | L | -10 |
| 13 | 2021-12-30 | Wisconsin (14) | 20 | Arizona State (58) | 13 | Final | W | 7 |