Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-01 | Central Michigan (60) | 44 | Oklahoma State (6) | 58 | Final | L | -14 |
| 2 | 2022-09-10 | South Alabama (118) | 38 | Central Michigan (60) | 24 | Final | L | -14 |
| 3 | 2022-09-17 | Bucknell (252) | 0 | Central Michigan (95) | 41 | Final | W | 41 |
| 4 | 2022-09-24 | Central Michigan (100) | 14 | Penn State (5) | 33 | Final | L | -19 |
| 5 | 2022-10-01 | Central Michigan (111) | 17 | Toledo (74) | 38 | Final | L | -21 |
| 6 | 2022-10-08 | Ball State (108) | 17 | Central Michigan (123) | 16 | Final | L | -1 |
| 7 | 2022-10-15 | Central Michigan (112) | 28 | Akron (152) | 21 | Final | W | 7 |
| 8 | 2022-10-22 | Bowling Green (99) | 34 | Central Michigan (124) | 18 | Final | L | -16 |
| 9 | 2022-11-02 | Central Michigan (113) | 35 | Northern Illinois (134) | 22 | Final | W | 13 |
| 10 | 2022-11-09 | Buffalo (91) | 27 | Central Michigan (99) | 31 | Final | W | 4 |
| 11 | 2022-11-16 | Western Michigan (125) | 12 | Central Michigan (115) | 10 | Final | L | -2 |
| 12 | 2022-11-25 | Central Michigan (124) | 19 | Eastern Michigan (108) | 38 | Final | L | -19 |