Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-08-28 | Alcorn State | 14 | North Carolina Central | 23 | Final | L | -9 |
| 2 | 2021-09-11 | Northwestern State | 10 | Alcorn State | 13 | Final | W | 3 |
| 3 | 2021-09-18 | Alcorn State | 21 | South Alabama | 28 | Final | L | -7 |
| 4 | 2021-09-23 | Alcorn State | 39 | Arkansas-Pine Bluff | 38 | Final | W | 1 |
| 5 | 2021-10-09 | Grambling | 20 | Alcorn State | 24 | Final | W | 4 |
| 6 | 2021-10-16 | Alcorn State | 24 | Mississippi Valley State | 12 | Final | W | 12 |
| 7 | 2021-10-23 | Alcorn State | 44 | Texas Southern | 27 | Final | W | 17 |
| 8 | 2021-10-30 | Alcorn State | 35 | Southern | 38 | Final | L | -3 |
| 9 | 2021-11-06 | Alcorn State | 31 | Bethune-Cookman | 35 | Final | L | -4 |
| 10 | 2021-11-13 | Prairie View A&M | 29 | Alcorn State | 31 | Final | W | 2 |
| 11 | 2021-11-20 | Alcorn State | 10 | Jackson State | 24 | Final | L | -14 |