Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-05 | Tennessee State | 10 | Grambling | 16 | Final | L | -6 |
| 2 | 2021-09-11 | Tennessee State | 16 | Jackson State | 38 | Final | L | -22 |
| 3 | 2021-09-18 | Kentucky State | 7 | Tennessee State | 41 | Final | W | 34 |
| 4 | 2021-09-25 | Tennessee State | 14 | Southeast Missouri State | 47 | Final | L | -33 |
| 5 | 2021-10-02 | Tennessee State | 24 | Austin Peay | 22 | Final | W | 2 |
| 6 | 2021-10-16 | Tennessee Tech | 13 | Tennessee State | 20 | Final(OT) | W | 7 |
| 7 | 2021-10-23 | Tennessee State | 28 | Eastern Illinois | 0 | Final | W | 28 |
| 8 | 2021-10-30 | Murray State | 21 | Tennessee State | 27 | Final | W | 6 |
| 9 | 2021-11-06 | Tennessee State | 20 | Tennessee-Martin | 41 | Final | L | -21 |
| 10 | 2021-11-13 | Austin Peay | 36 | Tennessee State | 7 | Final | L | -29 |
| 11 | 2021-11-20 | Tennessee State | 10 | Mississippi State | 55 | Final | L | -45 |