Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | North Carolina A&T | 18 | Furman | 29 | Final | W | 11 |
| 2 | 2021-09-11 | Furman | 26 | Tennessee Tech | 0 | Final | W | 26 |
| 3 | 2021-09-18 | Furman | 7 | North Carolina State | 45 | Final | L | -38 |
| 4 | 2021-09-25 | Mercer | 24 | Furman | 3 | Final | L | -21 |
| 5 | 2021-10-09 | Furman | 42 | Wofford | 20 | Final | W | 22 |
| 6 | 2021-10-16 | The Citadel | 14 | Furman | 24 | Final | W | 10 |
| 7 | 2021-10-23 | East Tennessee State | 17 | Furman | 13 | Final | L | -4 |
| 8 | 2021-10-30 | Furman | 3 | Chattanooga | 13 | Final | L | -10 |
| 9 | 2021-11-06 | Furman | 42 | Western Carolina | 43 | Final | L | -1 |
| 10 | 2021-11-13 | Virginia Military | 31 | Furman | 37 | Final | W | 6 |
| 11 | 2021-11-20 | Furman | 41 | Samford | 34 | Final | W | 7 |