Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-02 | Tennessee Tech | 14 | Samford | 52 | Final | L | -38 |
| 2 | 2021-09-11 | Furman | 26 | Tennessee Tech | 0 | Final | L | -26 |
| 3 | 2021-09-18 | Tennessee Tech | 0 | Tennessee | 56 | Final | L | -56 |
| 4 | 2021-09-25 | Eastern Illinois | 28 | Tennessee Tech | 14 | Final | L | -14 |
| 5 | 2021-10-02 | Southeast Missouri State | 17 | Tennessee Tech | 28 | Final | W | 11 |
| 6 | 2021-10-09 | Tennessee Tech | 27 | North Carolina Central | 16 | Final | W | 11 |
| 7 | 2021-10-16 | Tennessee Tech | 13 | Tennessee State | 20 | Final(OT) | L | -7 |
| 8 | 2021-10-23 | Virginia Lynchburg | 13 | Tennessee Tech | 56 | Final | W | 43 |
| 9 | 2021-11-06 | Tennessee Tech | 27 | Murray State | 32 | Final | L | -5 |
| 10 | 2021-11-13 | Tennessee-Martin | 42 | Tennessee Tech | 3 | Final | L | -39 |
| 11 | 2021-11-20 | Tennessee Tech | 20 | Austin Peay | 48 | Final | L | -28 |