Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-02 | Point University | 0 | Mercer | 69 | Final | W | 69 |
| 2 | 2021-09-11 | Mercer | 14 | Alabama | 48 | Final | L | -34 |
| 3 | 2021-09-25 | Mercer | 24 | Furman | 3 | Final | W | 21 |
| 4 | 2021-10-02 | Samford | 42 | Mercer | 45 | Final | W | 3 |
| 5 | 2021-10-09 | Mercer | 34 | Western Carolina | 24 | Final | W | 10 |
| 6 | 2021-10-16 | Virginia Military | 45 | Mercer | 7 | Final | L | -38 |
| 7 | 2021-10-23 | Wofford | 14 | Mercer | 45 | Final | W | 31 |
| 8 | 2021-10-30 | Mercer | 34 | The Citadel | 7 | Final | W | 27 |
| 9 | 2021-11-13 | Chattanooga | 6 | Mercer | 10 | Final | W | 4 |
| 10 | 2021-11-20 | Mercer | 35 | East Tennessee State | 38 | Final | L | -3 |