Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-02 | South Florida | 0 | North Carolina State | 45 | Final | W | 45 |
| 2 | 2021-09-11 | North Carolina State | 10 | Mississippi State | 24 | Final | L | -14 |
| 3 | 2021-09-18 | Furman | 7 | North Carolina State | 45 | Final | W | 38 |
| 4 | 2021-09-25 | Clemson | 21 | North Carolina State | 27 | Final(OT) | W | 6 |
| 5 | 2021-10-02 | Louisiana Tech | 27 | North Carolina State | 34 | Final | W | 7 |
| 6 | 2021-10-16 | North Carolina State | 33 | Boston College | 7 | Final | W | 26 |
| 7 | 2021-10-23 | North Carolina State | 30 | Miami | 31 | Final | L | -1 |
| 8 | 2021-10-30 | Louisville | 13 | North Carolina State | 28 | Final | W | 15 |
| 9 | 2021-11-06 | North Carolina State | 28 | Florida State | 14 | Final | W | 14 |
| 10 | 2021-11-13 | North Carolina State | 42 | Wake Forest | 45 | Final | L | -3 |
| 11 | 2021-11-20 | Syracuse | 17 | North Carolina State | 41 | Final | W | 24 |
| 12 | 2021-11-26 | North Carolina (53) | 30 | North Carolina State (27) | 34 | Final | W | 4 |
| 13 | 2021-12-28 | UCLA (42) | 0 | North Carolina State (27) | 0 | Cancelled | - | - |