Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-02 | Austin Peay | 30 | Chattanooga | 20 | Final | L | -10 |
| 2 | 2021-09-11 | Chattanooga | 20 | North Alabama | 0 | Final | W | 20 |
| 3 | 2021-09-18 | Chattanooga | 23 | Kentucky | 28 | Final | L | -5 |
| 4 | 2021-10-02 | Western Carolina | 17 | Chattanooga | 45 | Final | W | 28 |
| 5 | 2021-10-09 | Chattanooga | 34 | Virginia Military | 37 | Final(OT) | L | -3 |
| 6 | 2021-10-16 | East Tennessee State | 16 | Chattanooga | 21 | Final | W | 5 |
| 7 | 2021-10-23 | Chattanooga | 55 | Samford | 13 | Final | W | 42 |
| 8 | 2021-10-30 | Furman | 3 | Chattanooga | 13 | Final | W | 10 |
| 9 | 2021-11-06 | Chattanooga | 35 | Wofford | 10 | Final | W | 25 |
| 10 | 2021-11-13 | Chattanooga | 6 | Mercer | 10 | Final | L | -4 |
| 11 | 2021-11-20 | The Citadel | 24 | Chattanooga | 21 | Final | L | -3 |