Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Wofford | 24 | Elon | 22 | Final | W | 2 |
| 2 | 2021-09-18 | Kennesaw State | 31 | Wofford | 10 | Final | L | -21 |
| 3 | 2021-09-25 | Wofford | 23 | Virginia Military | 31 | Final | L | -8 |
| 4 | 2021-10-02 | Wofford | 21 | East Tennessee State | 27 | Final | L | -6 |
| 5 | 2021-10-09 | Furman | 42 | Wofford | 20 | Final | L | -22 |
| 6 | 2021-10-16 | Samford | 27 | Wofford | 24 | Final | L | -3 |
| 7 | 2021-10-23 | Wofford | 14 | Mercer | 45 | Final | L | -31 |
| 8 | 2021-10-30 | Western Carolina | 41 | Wofford | 21 | Final | L | -20 |
| 9 | 2021-11-06 | Chattanooga | 35 | Wofford | 10 | Final | L | -25 |
| 10 | 2021-11-13 | Wofford | 44 | The Citadel | 45 | Final(OT) | L | -1 |
| 11 | 2021-11-20 | Wofford | 14 | North Carolina | 34 | Final | L | -20 |