Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Eastern Kentucky | 31 | Western Carolina | 28 | Final | L | -3 |
| 2 | 2021-09-11 | Western Carolina | 0 | Oklahoma | 76 | Final | L | -76 |
| 3 | 2021-09-18 | Samford | 42 | Western Carolina | 37 | Final | L | -5 |
| 4 | 2021-09-25 | Western Carolina | 34 | Gardner-Webb | 52 | Final | L | -18 |
| 5 | 2021-10-02 | Western Carolina | 17 | Chattanooga | 45 | Final | L | -28 |
| 6 | 2021-10-09 | Mercer | 34 | Western Carolina | 24 | Final | L | -10 |
| 7 | 2021-10-23 | Western Carolina | 45 | The Citadel | 31 | Final | W | 14 |
| 8 | 2021-10-30 | Western Carolina | 41 | Wofford | 21 | Final | W | 20 |
| 9 | 2021-11-06 | Furman | 42 | Western Carolina | 43 | Final | W | 1 |
| 10 | 2021-11-13 | East Tennessee State | 56 | Western Carolina | 35 | Final | L | -21 |
| 11 | 2021-11-20 | Western Carolina | 52 | Virginia Military | 24 | Final | W | 28 |