Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | North Carolina A&T | 18 | Furman | 29 | Final | L | -11 |
| 2 | 2021-09-10 | North Carolina A&T | 17 | Duke | 45 | Final | L | -28 |
| 3 | 2021-09-25 | North Carolina Central | 14 | North Carolina A&T | 37 | Final | W | 23 |
| 4 | 2021-10-02 | Robert Morris | 14 | North Carolina A&T | 41 | Final | W | 27 |
| 5 | 2021-10-09 | North Alabama | 34 | North Carolina A&T | 38 | Final | W | 4 |
| 6 | 2021-10-16 | North Carolina A&T | 0 | Kennesaw State | 14 | Final | L | -14 |
| 7 | 2021-10-23 | North Carolina A&T | 9 | Hampton | 30 | Final | L | -21 |
| 8 | 2021-10-30 | Monmouth | 35 | North Carolina A&T | 16 | Final | L | -19 |
| 9 | 2021-11-06 | North Carolina A&T | 21 | Charleston Southern | 18 | Final | W | 3 |
| 10 | 2021-11-13 | North Carolina A&T | 27 | South Carolina State | 17 | Final | W | 10 |
| 11 | 2021-11-20 | Gardner-Webb | 35 | North Carolina A&T | 27 | Final | L | -8 |